Varanasi: Researchers from the Department of Pharmaceutical Engineering and Technology at the Indian Institute of Technology (Banaras Hindu University) have developed an innovative oral bioactive glass formulation for the treatment of gastro-duodenal ulcers, a common form of peptic ulcer. The formulation contains micro-ionized barium oxide (BaBG) which has proven therapeutic and protective effects against gastric and duodenal cancers.
Professor Sairam Krishnamurthy, who has developed the treatment with his team, explained that current treatments like the Proton Pump Inhibitors (PPIs) and Histamine Type 2 Receptor Blockers can have side- effects in the long term and therefore there is a need for safer alternatives. The present formulation will neutralize stomach acid, reduce the severity of ulcers, and promote cell growth to aid healing. In addition, it will form a protective layer to shield ulcers from harmful agents to prevent the condition from worsening.
Highlighting the gravity of the situation, Professor Krishnamurthy said that peptic ulcers affect 11.22% of India’s population, with duodenal ulcers having a global presence of 3%. These ulcers are more common in men and are generally caused by H. pylori infection, non-steroidal anti-inflammatory drugs (NSAIDs), smoking, daily use of aspirin, and gastrointestinal cancers. They are caused when the stomach’s acidic defense is compromised which leads to ulcer formation.
