Sunday, January 17, 2021
No menu items!

Game Changing Treatment for Cancer Soon? Swarna Jayanti Fellow of DST may have Answers

Must Read

India-Japan To Work Closely on 5G, Telecom Security & Smart Cities

New Delhi: India and Japan signed MoU to enhance cooperation in the field of Information and Communications Technologies on...

India Starts Vaccination Drive Today, PM Urges Not to Fall For Rumours Over Vaccines

New Delhi: The nationwide COVID-19 vaccination drive has been launched by Prime Minister Narendra Modi today morning. The vaccination...

Thiruvananthapuram Smartly Surpasses other Smart Cities

Surpassed Round -1 and Round – 2 Smart Cities in implementation Took a leap to 46th rank from...

New Delhi: Removing cancer cells at an early stage may be possible in near future. Dr. R. Mahalakshmi, Associate Professor, Indian Institute of Science Education and Research (IISER) Bhopal, a recipient of this year’s SwarnaJayanti Fellowship of the Department of Science & Technology (DST), Government of India, plans to identify molecular regulators that link mitochondrial VDAC proteins, which cell life and death (apoptosis), to cancer.

Scientists are working on new methods of cancer treatment, which will remove and eliminate cancerous cells at an early stage of development. One such method is with the help of mitochondrial membrane proteins called Voltage-Dependent Anion Channels (VDACs) that control cell life and death. This removal and elimination (called apoptosis), if done at the early stages of cancer onset, will lower the financial burden on Indian society.

Three forms of VDAC exist in human mitochondria. Her research goals are directed towards identifying VDAC isoform-specific target sites that can be used for drug design and the development of effective medical interventions. Potent drugs targeting membrane proteins are exceedingly limited because these biomolecules are linked intricately with multiple indispensable functions in every cell. Particularly, mitochondrial membrane proteins undergo subtle changes in their regulation in several cancers. Hence, it has now become important to identify these subtle regulatory differences in these proteins under normal conditions and disease states.

By identifying differences between the different VDACs under normal conditions and disease states and characterizing these biomolecular differences, Dr. Mahalakshmi will generate ways to track and tackle cancer. Using information about molecular demarcating elements between these proteins, she will design and develop peptide-based targeted therapeutics that could inhibit mitochondrial membrane proteins in cancerous cells.

“My future research will additionally provide detailed insight on how cellular processes are regulated through mitochondria, and how the alterations in mitochondrial permeability during cancer impact other cellular processes like calcium balance, redox levels, and utilization of the energy produced by mitochondria. In addition to cancer, my work will also contribute to developing effective therapeutics for several neurodegenerative diseases,” Dr. Mahalakshmi pointed out.

In collaboration with pharmaceutical companies, Dr. Mahalakshmi envisions working towards customized therapeutics based on designed peptide-based mimetics of VDACs, as a direct outcome of the research.

“I strongly believe that promoting apoptosis at early stages of cancer onset is both advantageous and will lower the financial burden on Indian society. My research, and the development of peptidomimetic inhibitors, will lead to pharmacologically tractable solutions and effective medical interventions affordable by the Indian community,” she added.

- Advertisement -

LEAVE A REPLY

Please enter your comment!
Please enter your name here

- Advertisement -

Latest News

India-Japan To Work Closely on 5G, Telecom Security & Smart Cities

New Delhi: India and Japan signed MoU to enhance cooperation in the field of Information and Communications Technologies on...

India Starts Vaccination Drive Today, PM Urges Not to Fall For Rumours Over Vaccines

New Delhi: The nationwide COVID-19 vaccination drive has been launched by Prime Minister Narendra Modi today morning. The vaccination drive has sett off India...

Thiruvananthapuram Smartly Surpasses other Smart Cities

Surpassed Round -1 and Round – 2 Smart Cities in implementation Took a leap to 46th rank from 90th rank Most projects in...

Tamil Nadu becomes 11th State to Complete One Nation One Ration Card System Reform

Chennai: Tamil Nadu has become the 11th State in the country to successfully undertake “One Nation One Ration Card system” reform stipulated by the...

India’s Active Caseload further contracts to 2.13 Lakh

New Delhi: India’s total Active Caseload continues to manifest a sustained downward movement. It has dropped to 2.13 lakh (2,13,027) on Friday. India’s present...
- Advertisement -

More Articles Like This

- Advertisement -